I was really surprised by this and can't find one thing about it. ????? From what he said I got the impression that it is at higher doses. Doc said at lower compounded doses may not be a problem but he didn't want to take chances on people with known nerve damage. You would think there would be at least one article on this in Pubmed. I will have to ask next time as there are such good reports on LDN...hmmmm.