I don't know what to make of this ( maybe it's even just coincidence). The areas that I rub my compounded cream on twitch, shake and vibrate less than normal. My cream has 10% Diclofenac and 2% amitriptyline. Diclofenac is an antiinfmammatory. Do u think my vibrating may be thousands of muscle spasms happening very quickly due to tight/tense or inflamed muscles? This symptom ( twitching and vibrating ) were my first ones and have been with me every second of the day for a year. Happen every second in all areaS at the same time ( hundreds all over every minute) effects do wear off after a few hours. I HSve been taking extra strength Advil but it doesn't seem to do the same thing. Tonight before bed I only put the cream on my feet ( both) left side of lower back and left side of neck. My entire left side of body is vibrating much less. Thus is odd bc both sides of my body do this equally. I don't know.. Anybody with more knowledge care to throw their two cents in?