Quote:
Originally Posted by johnt
Girija mentions tyrosine kinase inhibitors.
If we assume that:
- tyrosine kinase inhibitors are an effective treatment for PD.
- any commercial drugs will take at least five years to get to market and even then be too expensive for many.
Then it make sense to see if there are any natural substances with this property.
A quick Google gives:
- curcumin;
- genistein (found in broad (fava) beans, soybeans, coffee, kudzu).
Rick mentioned genistein back in 2012:
http://neurotalk.psychcentral.com/sh...ight=genistein
A quick sanity check:
- epidemiological results suggest that coffee consumption is negatively associated with PD.
- genistein crosses the BBB.
John |
Further tyrosine kinase inhibitors activate AMPK which initiates autophagy so
gynostemma tea should help PWP!
As researchers continue to unravel the mysteries of AMPK, they have discovered four ways to boost the body’s AMPK activity:
Exercise: AMPK activity increases with regular vigorous exercise.73 This beneficial effect of exercise on AMPK, however, may vanish in the elderly.5
Calorie Restriction: When you under eat, you create increased AMPK activity as cells sense a requirement to function more efficiently in the presence of diminished energy (food) intake. However, when normal food intake resumes, AMPK activity declines.74,75
Metformin: One of the drug metformin’s most beneficial mechanisms is to activate AMPK.76 This is one way it lowers elevated glucose.77 Unfortunately, most physicians only prescribe metformin for type II diabetes, making access to this drug difficult for most people. Some people also experience digestive upset in response to metformin and cannot take it.78
Botanical Extracts: Two natural agents (the
Chinese herb Gynostemma pentaphyllum79 and trans -tiliroside derived from rose hips80) have been shown to activate AMPK. Each of these agents triggers different downstream metabolic benefits, and in one study, trans-tiliroside led to an even greater glucose-lowering effect than the AMPK-activating antidiabetic drug metformin.81
With these four documented methods of boosting AMPK signaling, there is no reason for aging humans to suffer the degenerative impact caused by loss of activated AMPK.
As Gynostemma is a blood thinner be sure to talk with your MD before taking this herb.
http://www.lef.org/Magazine/2014/SS/AMPK/Page-01?p=1