The CRs have various forms of cellulose in them, thus the sticky blob they turn into. When the stomach empties, the pancreas secretes bicarbonate to neutralize the stomach acid and then the CR products let go of the drug for upper intestine absorption.
Some CR products use this type of matrix for the second round of the delayed release. The beginning IR is often in the coating of the tablet or capsule. There are many variants on this, with many scenarios....so one explanation will not fit all products.
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Weezie looking at petunias 8.25.2017
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