My experience with Rytary has been very positive. I was taking Stalevo 100 every four hours with 1 1/2 hours off time each. I switched to taking the 245 dosage of Rytary every four hours with basically no off times. I do not have the super high spike of Stalevo, however, after three weeks I see dramatic improvement in my movement, awareness, flexibility, stamina. I am also taking Amantadine ER for dyskinesia, one Azilect each morning, and Mirapex three times per day. Be patient with the Rytary as the benefits seem to compound over time.