Quote:
Originally Posted by Tupelo3
Actually, the relationship between cerebral fluid a-syn and PD is negative. People with PD have lower levels, not higher. The thought is that the a-syn is staying in the brain, aggregating as the neurons fail to dispose of them as waste. Keep in mind, it's not the level of a-syn that is thought to be the problem. The theory is it's the mutation into a misfolded form that causes the problem.
http://www.uphs.upenn.edu/news/News_...2013/08/shaw2/ |
Thanks for that info. I did see a similar study which I thought showed lower alpha syn levels for PD patients. Does this mean that the present 2 clinical trials to lower Alpha Synuclein levels won't likely be much help to treat PD?