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NUTRITIONAL MEDICINE RESEARCH
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PROTOCOL
The use of RG-40 Concentrated Organic Vegetable Extract with MSA and Parkinson’s Disease.
AS STATED IN STAGE 2 OF THE NUROGENIC DIET
Nutritional Medicine Research UK.
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1. - During the first ten days, the patient should try to establish the dosage required to produce the optimum effect.
It is advisable to take the RG-40 Extract on an empty stomach, first thing in the morning. The Extract must be taken instead of one of any of the morning dosages of the different drugs usually taken for PARKINSON’S DISEASE.
On the first day, it is recommended to start with half a teaspoonful of the Type RG-40. The second day you can increase it 3/4 of a teaspoonful and then, if required, increase it each morning up to two teaspoonfuls.
Food can be taken as normal, half an hour after taking the Type RG-40. During this initial period, while finding the ideal dosage, RG-40 should be taken only once a day, in the morning. The rest of the day, all other medications should be taken as usual.
2. - During this initial trial, the patient must try to identify the ideal dosage of the Type RG-40 that is suitable for his condition. The dose will depend on absorption, tissue transport and the stage of the disease. When adjusting the dose, take the following into consideration:
· Too much Type RG-40 will produce some nausea or some form of dyskinesias (these are the large involuntary movements caused by an overdose.) Nausea represents the natural response of the body to protect against a too high dopaminergic activity.
· The patient who has taken too small a dose will have almost no response. Here the dose should be increased the next morning. The first response to the Type RG-40 is an evident release of rigidity that generally occurs one hour after taking it.
· Once the ideal dose of the RG-40 required to produce an optimal response has been determined, a second dosage of anti-Parkinsonian drugs, can be replaced by the RG-40.
In the long term, replacing anti-Parkinsonian drugs by the natural extract will reduce or eliminate most of their unwanted side effects.
3. - RG-40 produces a clear improvement in the patient’s ability to move, walk, speak and exercise. It controls but does not eliminate tremour. It improves balance, reduces constipation and increases hours of good sleep. The use of the RG-40 does not produce dryness of mouth, constipation, loss of balance, hallucinations, incontinence, freezing episodes or any of the other common adverse reactions of some Anti Parkinsonian drugs.
Patients who have found their ideal dosage use between 1 and 2 teaspoonfuls of RG-40 on an empty stomach, a maximum of three times a day.
4. - Patients taking drugs like Sinemet more than five times a day usually develop adverse reactions. These side effects increase with higher doses of drugs. Patients using Sinemet 10 more 12 times a day are usually suffering very evident and distressing side effects. With the help of this organic extract, patients depending on high dosage of drugs are able to reduce the use of these drugs to customary levels and thus minimize their side effects.
5 - The bottle of RG-40 in use should be kept in the refrigerator but the bottles to be stored must be kept in the freezer. Mixing a tablespoonful of warm water and honey with the extract when taking it, will facilitate its absorption.
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RG-40
Molecular Neurobiology of Dopamine Receptor Synthesis induced by RG-40
RG-40 is an organic vegetable extract, rich in amino acids and plant kingdom biological factors, required for the synthesis of neuronal dopamine receptors.
RG-40 natural components are organic substances which are easily allowed to penetrate the blood brain barrier and can access the Basal Ganglia, where they interact with the DNA of dopaminergic neurons.
RG-40 biological factors are transported inside the dopaminergic neurons reaching the nucleus, where they interact with DNA.
DNA in the cell nucleus is the command centre where orders to carry out the synthesis of receptor proteins are executed.
5.- Shown in this graph is the molecular neurobiology of dopamine receptor synthesis.
6.- The process begins in the cell nucleus, where RG-40 activates specific genes, which induce DNA to be transcribed into messenger RNA.
7.- Messenger RNA then travels to the endoplasmic reticulum where ribosomes cause the messenger RNA to be translated into partially formed dopamine receptor proteins.
8.- The next step is for partially formed dopamine receptor proteins to be transformed into complete dopamine receptor molecules in the Golgi Apparatus.
Completely formed dopamine receptor molecules are proteins and these are transported to the cell membrane where they interact with the neurotransmitter dopamine.
As a result of the interaction between the neurotransmitter dopamine and dopamine receptor molecules, the ability of our muscular system to perform movements is regulated.
Neuronal dopamine receptor deficiency causes motor disability problems, such as those observed in conditions like MSA-P and Parkinson’s Disease.
Most drugs available today to treat Parkinson’s Disease attempt to increase the concentration of the neurotransmitter dopamine or its agonists in areas of the brain which are affected in Parkinson’s disease. However, the activity of these drugs is limited by the number of neuronal dopamine receptors available to interact with the neurotransmitter dopamine or its drug agonists.
No matter how much a patient increases the dosage of dopamine precursors like Sinemet, or of any of the dopamine agonists drugs, if there are not enough neuronal dopamine receptors to interact with, these drugs will not produce any further response at all.
14.- This figure is a schematic diagram of a dopamine receptor showing that it is a protein arranged essentially as a long chain of amino acids.
15.- The chain of amino acids, forming the dopamine receptor, winds in and out of the cell several times. This creates three regions of the receptor. Firstly, the extra-cellular portions are those parts of the chain entirely outside the neuron; secondly, the intracellular portions are those segments of the chain entirely inside the neuron and thirdly, the trans-membrane portions, which are the regions of the receptor which reside within the membrane of the neuron.
16.- Each and all of the amino acid and biological factors required for the synthesis of this and other dopamine receptor molecules, are present in the organic vegetable extract RG-40, which is now used by all the PD and MSA patients participating in our studies.
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2a. Research on Neurogenesis
Script and slides from the documentary:
“Original Home Video Clips Showing the Genuine Personal Experiences of Parkinson’s Disease and MSA Sufferers.”
2c. The Neurogenic Diet in the Treatment of Neuro-degenerative Disorders
Basic proposal for clinical studies concerning MSA and Parkinson’s Disease.
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