It is best to take them all at once in the morning. This mimics the body's physiological secretion of cortisol.

I had a toxic spider bite... that had a possible infection. I didn't think taking so much with an infection was a good idea.

I had let it go for about a week... taken care of it well...but it hurt so much I had to soak it in the cold lake. Then a creeping geographic rash started moving down into my foot. This bite was on the outside ankle bone. The center of the bite started turning black. (this I found out is a necrotizing reaction to the venom.) My ankle hurt for a long time after that. In fact it is my touchy left ankle of the foot I had surgery on 50+ yrs ago...
It has never been quite the same since.

Doctors like to give big bolus doses of steroids... but I felt that it was my body, and I should have a say too. So I did it my way.

The doctor up there said these were common...his wife had one from the golf course! Mine showed up from sitting on the dock barefooted, watching shooting stars at night. I thought it was a mosquito bite at first...but the doctor said no...there were two punctures like a spider makes. He put me on Zithromax antibiotic, the Prednisone and strong dose of Atarax.

That trio did the trick.