I had been using RequipXL before the Neupro and my MDS told me that 8mg requip = 6mg. Neupro, so I just switched with no problem. I had to leave RequipXL when they switched to a generic med and I reacted poorly to that (6--8 hours of nausea each day). When we added Sinemet, we went back to RequipXL (non-generic...quite expensive) but I have many benefits and few side effects so far. This has been a year.