The majority of tolerance to OPIATES... involves the brain's glial cells stimulating the formation of new, more numerous receptors.
NSAIDs as a rule do not cause tolerance this way.
NSAIDs used constantly (over about 6 wks) will then block any healing attempts at the tissue level.
NSAIDs in the short run block inflammatory cytokines which can cause pain. In the long run some Cox-2 cytokines are involved with healing so LONG term NSAIDs result in damage.
These issues are reflected in studies over that past 10 yrs or so.
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Weezie looking at petunias 8.25.2017
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