You might think about every other day or every 3rd day dosing too. IF you are a MTHFR candidate, it will take time to build up with supplements.

You know that Deplin 7.5mg (methylfolate) -- such a high dose--- never really worked for the reasons it was approved...for depression.
I read many depression forums where the patients just hated it.
Called it useless.

I'd do the B12 daily however, as it is much more critical.

I do know that I just cannot take methylfolate every day.
I also use B-right by Jarrow, though, and it 3 times a week.
I've never confirmed MTHFR for myself. My B12 has been high without vitamins... 849. With 5mg of methylB12 daily for 3 months it went up to 1999!. I don't think I have the polymorphism myself.

For a while Merck refused to sell methylfolate OTC anymore and so it was not available. But about 5 yrs ago they changed their minds when Deplin failed, and now it is back OTC by several makers. Merck make all the raw vitamin and licenses it out to various makers.(including some RX ones)