Don't expect much effect from the 2mg patch. You'll see greater benefits from the higher dosage. There seemed to me to be some meds left in the patch so I would leave the first one on when I put the second one on so I didn't have to wait for it to kick in.

For sure move the placement around unless you want chemical burns.

I never had a problem with putting it on a little later.

I don't use Neupro now.