It takes time for SAMe to work. You have to rebuild tissue lost after all. I started at 200mg a day (it was very expensive then), and slowly raised to 600mg a day.
Now I just take 400mg a day. I've tried to quit it, but my pain keeps coming back without it. So I am back on again (3rd time).
It is best to build slowly up in dose IMO. The chemistry has to be rekindled for healing if it has stopped.
People with poor acid in the stomach may dissolve the enteric coating prematurely before the tablet can get to the intestine.
I think that is where the nausea comes from...the tablet dissolving in the stomach where it does not belong.
It is best to take it before eating...that way it will move along quickly and not dissolve in the stomach. In Europe they had only injectable form, you know.
__________________
All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei
************************************
.
Weezie looking at petunias 8.25.2017
****************************
These forums are for mutual support and information sharing only. The forums are not a substitute for medical advice, diagnosis or treatment provided by a qualified health care provider. Always consult your doctor before trying anything you read here.