I started it the first year my son started college....it was on sale on an endcap at WalMart's. I was there buying stuff for the dormitory --shower stuff toothpaste etc. It was about $15.00 for 10 tablets of 200mg. (my son will be 34 this month and was 18 at the time). I had just had my MRI on the knee too. It showed synovitis. After a month using it I knew I would continue. It gave me lots of energy which during the post menopausal times I really needed for work.

I managed the pain standing at work with my neodymium magnets.

I took the SAMe for over a decade every day. I stopped about 3 yrs ago thinking I didn't need it anymore. But I was wrong. The process creating the pain started up again. I had thought I had rebuilt my knee. But I was foolish... the process is going to continue forever to destroy it. So I am back on it each morning.
And already in a week I am seeing small improvements (not needing my brace, etc). This is much faster than before.

SAMe is a slow rebuilding supplement. It is not quick like drugs, for pain. But it is one of the few (if any) things with medical research behind it.