The only disclaimer I know of is IF ON PHARMA BLOOD THINNER THEN YOU CAN'T TAKE BOTH, ONE OR THE OTHER.

My main OPC is grape seed extract, vitacost sells a muscadine grape seed that is high in resveratrol and I take it also...I work with both the extract and pain grape seed.

I took Pycnogenol for the first year in 1995 and then tons of research, read books, own books, I did it all.

I take so many supps and there has never been an issue for me in almost 20 yrs....

These OPC's strengthen our IMMUNE SYSTEMS...work on circulation and clean our sticky, dirty blood.

I take my 200mg grape seed ex first thing in morning on empty stomach, I've never had a stomach issue, but if one does, take it with food. The 500mg grape seed (Muscadine cap) from vitacost, I take much later in the day. This is what I do, you can start lower and work up, learn to work with OPC's....we need to take enough for our bodyweight. C