The older form (that is both S- and R-) should be taken on an empty stomach. There is a study showing reduced absorption when taken with food up to 30% reduced. Only the R is active.
So doses tend to be higher to compensate for the inactive S form.
The newer forms, can be taken anytime. This is called stabilized NaRala.... and is more soluble and more effective. Usually only 100mg is needed daily of this type.
Labels on supplements don't always have accurate information on how to use them.
This is a fairly complete monograph:
http://lpi.oregonstate.edu/mic/dieta...rs/lipoic-acid
Quote:
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Since taking LA with a meal decreases its bioavailability, it is generally recommended that LA be taken on an empty stomach (one hour before or two hours after eating).
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Weezie looking at petunias 8.25.2017
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