“Dividing up your dose thru the day may result in better absorption. But that depends on how much transcobalamin is available in the small intestine to accept the B12 for transport. Research into transcobalamin is still new however.”

Hi mrsD, would you mind elaborating a little more on your understanding of this new transcobalamin research? What factors determine how much is available for B12 transport?

Usually I read that methylcobalamin should be taken in one large dose per day. I used to take 5000 mcg once daily, but I did recently switch to taking 3000 mcg in the a.m. and 2000 mcg in the p.m. because I thought it might help with absorption, but this was not based on anything scientific. Thank you!!