janieg, I see you take grape seed ex and I was going to mention it since it does reduce histimines, it's anti histimine, anti fungal, anti bacterial properties in this OPC. Maybe consider taking 250mg a couple times a day and see if you can get results. I take at least 400mg grape seed ex daily, one of my products is Muscadine grape seed from vitacost and it is 500mg cap...I take it daily and 200mg grape seed Extract cap too.

I realize I don't have all the PN issues so many of you talk about but grape seed ex has been a life changer for me in so many ways. I know when I had a couple bouts of edema from a couple things, I upped grape seed ex to 600mg or more daily and got rid of edema...so I know it's so effective for so many issues. And much is still unknown but more info comes out all the time as I find a lot of info. C