Well, this 5% cream that my wife will apply to myfoot/ankle. It feels to me it is deeper then nerves in my ankle/foot. I feel it in my calf as well. He said it will take 3 weeks to get used to. I tried it for 3 days but it hurt too much. But I'm in so much pain I'm gonna try it again. I canceled my pain clinic appointment thinking I may not need it. But I may reschedule at this point. All my joints are sore too. Mainly back and ankle/foot. Shoulder of course cuz I have a plastic bracket and rope holding it together. Thanks for the info and all. I check every 10 mins or so if I can.