Linus Pauling Institute: re: carnitine
http://lpi.oregonstate.edu/files/pdf...tters/ss13.pdf
The Linus Pauling Institute also had a very good evaluation of the controversial Vit E media rant a few years ago.
http://lpi.oregonstate.edu/mic/vitamins/vitamin-E
Quote:
Vitamin E supplementation and all-cause mortality
A meta-analysis that combined the results of 19 clinical trials of vitamin E supplementation for various diseases, including heart disease, end-stage renal failure, and Alzheimer's disease, reported that adults who took supplements of 400 IU/day or more were 6% more likely to die from any cause than those who did not take vitamin E supplements (73). However, further breakdown of the risk by vitamin E dose and adjustment for other vitamin and mineral supplements revealed that the increased risk of death was statistically significant only at a dose of 2,000 IU/day, which is higher than the UL for adults. Additionally, three other meta-analyses that combined the results of randomized controlled trials designed to evaluate the efficacy of vitamin E supplementation for the prevention or treatment of cardiovascular disease found no evidence that vitamin E supplementation up to 800 IU/day significantly increased or decreased cardiovascular disease mortality or all-cause mortality (74-76). Additionally, a more recent meta-analysis of 57 randomized controlled trials found that vitamin E supplementation, up to doses of 5,500 IU/day, had no effect on all-cause mortality (77). Furthermore, a meta-analysis of 68 randomized trials found that supplemental vitamin E, singly or in combination with other antioxidant supplements, did not significantly alter risk of all-cause mortality (78). At present, there is no convincing evidence that vitamin E supplementation up to 800 IU/day increases the risk of death from cardiovascular disease or other causes.
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The Linus Pauling Institute is part of Oregon State University and has had a very complete and evidence based attitude on using supplements. It remains IMO one of the best sources to consult concerning questions, and safe use of vitamins, minerals and other supplements. They have just redesigned their site to be more user friendly, and if you search an item you will find articles in addition to the basic monographs.
Readers here are always free to decide for themselves, but it really helps to have good sites to provide the data for those decisions.
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All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei
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Weezie looking at petunias 8.25.2017
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