I have many symptoms of sensory SFN - but haven't been officially diagnosed with it by the neuros I've seen.

I also recently found out that I have significant methylation profile issues. (I am homozygous for 4 gene mutations including the A1298C gene, and heterozygous for 8 other mutations. However, I am "normal" on the C677T gene.)

There's been a fair amount of discussion here about methylation issues and MTHFR mutations - but has anyone here really linked their neuropathy (particularly SFN) to their methylation issues?? And, have they seen any improvement in their neuropathy through supplementation to address the methylation issues??