Thanks janieg, based on the link you sent, I have the following status and issues:

CBS C699T (+/+) = homozygous defect. Both genes affected. Significant propensity for ammonia detoxification issue. Will need to be careful with sulfur containing supplements, ie. MSM and medications, ie. DMP

COMT V158M (+/-) = heterozygous. Partial defect in system = partial ability to use up CH3 groups. Will be able to handle some methylating supplements, ie. Methyl-12, SAMe, Theanine, DMG.

MTHFr C667T (-/-) = no mutation – enzyme works efficiently to convert homocysteine to methionine.

MTHFr A1298C (+/+) = homozygous mutation. Both genes affected. The enzymes system works very sluggishly which significantly impairs the conversion of BH2 to BH4 and its related effects.

MTR A2756G (+/-) = heterozygous mutation. Partial defect in system. This defect causes an INCREASE in enzyme function which increases the risk for methylation or methyl group depletion. Will be better able at handling a variety of methylating substances such as Methyl-B12, DMG, Theanine, SAMe, etc.
VDR Bsm/Taq (+/+) = homozygous mutation. Both genes affected. If mutation is present will be more sensitive to methyl donor supplements, ie. Methyl-B12, SAMe, DMAE, Theanine, DMG, TMG. Also, will need to watch for behavior issues related to fluctuations in dopamine production – mood swings!

So, with the A1298C mutation, there isn't the major issue with homocysteine. There's more of an issue with lack of BH4. And, some of the other issues seem to cancel each other out (one causing sensitivity to methyl donors, the others not, etc.) In addition, there's another half dozen mutations - so it all gets very confusing. I'm beginning to get some ideas on where to start, and will let you know how things come along.

Also, starting to search for an integrative medicine doctor in my area that has experience with treating complex methylation issues. Yeah I know - good luck with that, right ??