I am on Rytary ER 48.75 MG-195 MG CAP. I take 9 a day. 3 @ 7AM ,11AM and 3PM. It kicks in at about 7:30AM and lasts until about 7PM. I supplement the 3 dosages with 1 25-100 Sinemet at 5:30AM and if I stay up past 7:30 PM I take 1 Sinemet every 1 and 1/2 hours. The co-pay is $40 per month.
Overall it is better than remembering to take Sinemet every 1 and 1/2 hours. It is very sensitive to a lot of foods and should be taken at least an hour before or after food. Often about 10% of the time it doesn't kick in fully. I believe I have more naseua with it. It is no wonder drug and a little better than Sinemet.