you have my sympathies for sure, you have to deal with a lot more than pd.

the only thing i would point out is you can make the argument that 300mg CR may be only 60% bioavailable so your calculation would be 800mg + .60x300=980mg

are you sure those are 25/100mg CR? i guess you call them ER. I'd try to get the dr. to change the RX to 50/200 which can be split so you can vary the doseage. Maybe he doesn't want to give her RYTARY all day long but what about as the last dose of the day?

i certainly find it strange she isn't given any sinemet at bed and if she wakes up in the middle of the night, most pd'ers take a 50/200 at bed and keep sinemet by their bedside if they wake up.

too bad she can't take requipXL, i assume agonists are not an option at her age and medical condition?