I was taking 2 25/100 Sinemet every six hours, but was wearing off after four hours. So we added entcapone to the mix (200mg tablet) with the Sinemet and it had gotten me back to being good for six hours. 4am 10am 4pm 10pm (usually in bed at 10pm; alas awake a little after 1am). I need that 10pm does least the dystonia monster visits me.

Sadly my body keeps changing, and I seem to be getting 5 hours "on". I just don't want to increase the medication, but try to manage through the day as best as possible (when off on a bad day, near impossible to use a keyboard or mouse... so I use voice recognition on the computer)