I have just begun treatment but I can certainly tell the difference when I treat one leg vs the non treated leg. I was referred by my Oncologist to rehab for anodyne therapy.The local hospital does not charge for anodyne therapy if in conjunction will other therapy. Unfortunately, after a battery of tests it was determined that I did not have a serious loss of function (balance, strength, etc) so I did not qualify for rehab, ergo they would not treat me since pain only was not part of the criteria. So, I bought my own machine, which is the Anodyne Freedom model 300 which is designed for lower leg and foot treatment from Amazon. Will keep you posted on progress.