Somewhere I read that grape seed extract reduces allergic responses by acting as a natural anti-histamine. I’m sure it works that way for most people.

My experience, however, has been the opposite. I actually get quite ill whenever I try to drink wine or take any grape based supplements like grape seed extract, red wine extract or resveratrol. My mom also could not tolerate wine, so I suspect it is probably something genetic.

I don’t think there is any harm in trying grape seed extract, but I would start with a small dosage and then increase it if there is improvement in allergic symptoms.