Good question.

I think the relatively low rate of mention in this forum of rasagiline as compared to Sinemet, say, is due to:
- fewer of us are on it, so there's naturally fewer people posting about it;
- it has a limited effect: 1mg has a levodopa equivalent dose of about 100mg, which, although welcome, is a small part of the 1000mg levodopa equivalent daily dose that many of us take;
- its method of working means that its effect is almost constant through the day, so you just don't notice it.

I thought the claim of neuroprotection has not been proven. This is not the same as saying it has been proven not to be neuroprotective. I think we can view the results of the trials as indicating that, at best, there may be a small neuroprotective effect.

It seems to me that if you buy into the theory that changes in dopamine levels due to the drugs we take should be minimized as far as possible then rasagiline has a part, albeit a small part, to play.

John