Hello everyone,
yesterday morning I started taking XadagoŽ (safinamide) 50mg a day. For now it’s sold only in Germany, in order to shorten time to market. The "small" price is € 850 for a pack of 100 tablets. I must start by saying that I have a bradykinetic Parkinson for about 10 years, and my therapy is: Sirio (Melevodopa)100mg x 3, Stalevo (L-dopa+Entacapone) 150mg x 4, Neupro (Rotigotine) patch 12mg / 24h. Up to 20 days ago, I took it for a week Jumex (MAO-B Inhibitor) 5mg, but I had to stop it, because after a few days, I noticed that it was causing me confusion and poor concentration. For some time now I have some annoying moments of wearing off, and very slight dyskinesias on the peak dose. The package insert of the medicine it says to be careful not to overlap the XadagoŽ with other inhibitors of MAO-B (eg. Jumex) I had suspended for 20 days, but perhaps not enough time, perhaps it also needs 30 days, in fact, about an hour after I had taken XadagoŽ after breakfast, I started to feel like full-head sensation, and in fact my blood pressure had gone up a bit '. After about three hours I took 50mg of L-dopa, but I had not yet unlocked, after another 2 hours I took 100mg of L-dopa, but still with little success after another 2 hours I took 150mg and then I unlocked. The ON period lasted about three hours, then I started again 150mg of Stalevo and after another five hours an additional 150 mg of Stalevo.
This morning I woke up in ON and took 100mg of Sirio at 07:30 am, for now I think I do not retake XadagoŽ because I would experience if in general the timing of ON improve and to work off a bit 'of that feeling of full-head, due to the not very good blood pressure 137/87 mmHg.
I'll try again tomorrow.
Scheme as I assumed XadagoŽ:
06:30 am awakened and taken XadagoŽ, OFF
07:30 am feeling of full head,not very good blood pressure (137/87 mmHg), OFF
09:30 am took 50mg Madopar, OFF
11:30 am taken 100mg Madopar, OFF
01:30 pm took 150mg Madopar, OFF
02:30 pm ON, end of feeling full head, regular blood pressure (127/79 mmHg)
04:30 pm took 150 mg Stalevo, OFF
05:30 pm ON
10:30 pm took 150 mg Stalevo, OFF
11:30 pm ON , and sleep
this morning
05:30 am woken up and not taken anything, ON
07:30 am taken Sirio 100mg, OFF
08:00 am ON