Quote:
Originally Posted by mrsD
It also seems to me that providing MORE fish oil would eventually override or use up the enzyme, so perhaps until there is an inhibitor of the break down enzyme, maybe just a bit higher dose would help?
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That's what I was wondering. It would be an expensive experiment, but I might try it.
Interesting to my situation, I've seen estrogen referred to as an "sEH suppressor" in one report (can't drum it up at the moment), but this report seems to indicate the same:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972065/
Estrogen, soluble epoxide hydrolase & cardiovascular injury
"17β-estradiol may regulate an emerging novel therapeutic target against CVD – soluble epoxide hydrolase (sEH) . Arachidonic acid is converted to endogenous lipid epoxides epoxy-eicosatrienoic acids (EETs), which sEH (the cytochrome P450 [CYP] eicosanoids-metabolizing enzyme) degrades to 1,2-diols (dihydroxy-eicosatrienoic acids [DHETs]). High sEH levels decrease EETs and increase DHETs, whereas inhibitors of sEH increase the EETs to DHETs ratio in animal models."
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