Some can be so subtle but still "doing"something positive.

Some can be profound as I have had with grape seed ex and allergy/sinus issues. And edema also. And if it is preventing cancer, it's working.

Some may not do anything, but I like to give a supp a 3 month trial at least. Some may take longer to work in one's system.

I've gone off 2 supps in the last couple yrs and "knew it"...so went back on.