Personally I gave LDN a 6 month chance to work for me, as I so did not want a hip replacement. I never got past .5mg and first day I took that dose I had a wonderful good feeling and it never returned again. But kept trying with it for 6 months for the reason I said. The LDN group kept pushing me to stick with it. It also gave me some horrid constipation which I had to deal with, which I did with extra mag and Vit C.... So good luck whomever works with it...from what I recall the recommended dose is 4.5mg but I never got past .5mg....I could no imagine going higher with what I was experiencing....some did say they could not go higher either. I understand there is a lot of success with it and MS.