After 14 years on an SSRI, I would never go on a high dose SSRI again. I believe it permanently changed how my brain works. There is evidence to support that.

I am doing much better on 5-HTP and L-Theanine that I ever did on 60 mgs of paroxetine. The symptoms of serotonin syndrome were evident. The mood changes were evident. The flat affect was miserable.