Hi CD,
Sorry to hear about all the stressors you have right now. That is a lot to deal with without any pain or health issues. I personally have not noticed much change in mood due to my low dose ketamine infusions. I have now had four of them ranging between 25 to 37.5 mg total. And although my mood is generally good these days, there is occasional lowness as one would expect when dealing with physical limitations. I wouldn't complain about an overall boost!
My mood was impacted by neurontin and that ultimately led to my switching to nortriptyline. Certainly neurontin doesn't affect everyone that way but it made a big dent in my mood.
What I found to be the most helpful was going to therapy. I ended up wishing I had gone sooner. I waited and waited thinking I would get better physically and Not need it. But even if I got 100% better it would not have negated the trauma and loss I suffered. Ultimately, a therapist specializing in chronic health and pain issues helped me move through a very dark time resulting from the changes CRPS brought to my life and gave me better coping skills. She was certified in EMDR and hypnosis and I found both of those modalities to be very helpful. I found her on the Psychology Today website by looking at special interests.
If you do not have outside support right now I strongly encourage you to seek it. A support group, therapist or clergy can help you carry your current burdens. There is no need to go it alone.
Sending hugs,