To each his own-- somebody famous said that. When I first started out, I wanted to get better and I mean yesterday!!! After a couple of years I have learned a lot from Mrs.D and I-we all owe her so much. If you have baseline numbers such as B-12, you know if you need to supplement or not. If you don't know if you need it or not, its akin to buying insurance. And everyone knows how rich Warren Buffet is. I will always have to supplement B-12 as I was deficient due to years of Metformin and I will continue both. My Endo put me on the CoQ-10, nuff said. He said also that I needed the Gelcap of Vitamin D. I have discontinued 5 or 6 others for a time and do not feel any different. But what if I am messing up???? You see my point? I will always read everything from Mrs.D but I might not take everything I used to in the beginning. I also had a Neuro tell me to stop taking Zinc as a supplement(I had read something on You-Tube)there is a zinc-copper ratio that has to be tested for. My B-12 went from 119 to over 900 and only then did I stop monthly injections and maintain with Foltanx. That was the only difinitive numbers that I knew of. All the rest were"insurance". As a child you didn't know if you are a conservative or a liberal-a Baptist or a Methodist. If you are just getting started with supplements you just don't know which ones are going to be, " your own".