I did Rebif (makes the ABC's CRAB) which made me feel like the flu every 3 days, Novantrone which made me vomit but not lose my hair in that short time of doing nor (to kids' disappointment) pee blue (another potential side effect) and feel much better now without both.. For pain and discomfort doctor prescribed Vicotin which did nothing (I must be one of those Opnid resistant people) and with some physical behavior changes have no discomfort now. I know with MS everything could change in a blink of an eye.