Senior Member
|
|
Join Date: Apr 2009
Location: Stafford, UK
Posts: 1,059
|
|
Senior Member
Join Date: Apr 2009
Location: Stafford, UK
Posts: 1,059
|
Here's my briefing notes based on the referenced Medical Express article (the PNAS paper is behind a pay-wall):
In a rat model of Parkinson's it was found that:
- Nurr1, a protein found in the brain, "protects the brain's ability to generate dopamine neurons";
- activating Nurr1 in rats eliminated all symptoms of Parkinson's.
Nurr1 is activated by existing FDA approved anti-malarials, chloroquine and amodiaquine.
There would seem to me to be a good case for going ahead with clinical trials on the existing drugs. But no, they want to modify the drugs first, before carrying out clinical trials. Why?
Interestingly, there's a lot of claims in PwP sites around the web that quinine relieves PD, and a few claiming that it causes it.
John
__________________
Born 1955. Diagnosed PD 2005.
Meds 2010-Nov 2016: Stalevo(75 mg) x 4, ropinirole xl 16 mg, rasagiline 1 mg
Current meds: Stalevo(75 mg) x 5, ropinirole xl 8 mg, rasagiline 1 mg
|