The Benadryl is very important, but yes, it makes most people sleepy. Actually, sleeping during the infusion is very good for helping with reactions. If you cannot drive herself to/from after taking it, then maybe they would consider doing the infusions at home. The cost is considerably LESS (thousands less, actually) for home infusions, so most insurance companies jump at the idea. This way you could take the bendaryl and have a better experience (both with less side-effects and more sleep/rest).

The Zyrtec needs to be taken the day before, morning of infusion, and for a couple days after. Of course, there is no sleepiness that occurs with Zyrtec.

The other thing that can be considered if you just can't tolerate your side-effects, is to change the brand of product. What brand are you taking now?