As far as the fatigue - I think a lot of it was psychological. I had basically convinced myself that I had a fatal neurological disease, then find out that I didn't - only to later realize that I actually have a condition that won't kill me but may become horribly painful and debilitating. That can put you in a very dark place. I'm not sure what pulled me out of that place, things just got brighter over a period of time.

The other thing that seems to be helping is a multi-vitamin/mineral supplement I've been taking over the past month or so that is formulated for methylation support. I decided to try it due to the MTHFR and other methylation mutations I have. (I was already taking most of the standard PN supplements, but something seemed to click when I started to take this.)

If your interested I can give you the link to it, but I don't want to appear to be promoting it. It's not particularly cheap and its only been a month and I don't really know for sure what is doing for me - much less what it would do for anyone else.