Ditto on what Maurice is saying. A higher dose isn't necessarily better.

Mestinon does run out within 2-1/2 hours of taking it. It kicks in after about 30 minutes of taking it. So you are left with two good hours of increased acetylcholine getting to your muscles.

Speak to your neuro about this. Some people do better on a consistent dose throughout the day. Everyone is different and it might take some time to find the right balance for you!

Annie