Quote:
Originally Posted by kiwi33
Thanks DejaVu - those results are impressive.
Targeting IL-23 (guselkumab) as well as/instead of TNF (adalimumab) looks like a good plan to me.
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Hi Kiwi,
Its interesting!
Stelara targets IL-23 and IL-12.
A different drug, BI 655066, also targets the cytokine IL-23 (only).
Stelara and BI 655066 were compared in a trial.
In the Phase 1 Trial, BI 655066, performed better than Stelara.
"Earlier in March, data from a Phase I trial of BI 655066 were published in the Journal of Allergy and Clinical Immunology. In that trial, more than half of patients on the drug experienced at least a 90 percent improvement in psoriasis after three months, researchers reported."
BI 655066 has moved on to Phase 2 Trial.
https://www.psoriasis.org/advance/tr...r-than-stelara
It's appearing as though the idea of targeting IL-23 may be very helpful.
People really suffer with Psoriasis.
I've been fortunate to deal with only minimal skin psoriasis. I had started to experience more this year, yet still minimal. I do deal with progressing psoriatic arthritis and my treatment options are very limited due to co-existing medical conditions.
I am usually keeping an eye on the research.
Thanks for your feedback.
Warmly,
DejaVu