I would like to comment on this topic, especially the manufacturer suggestion to drastically up the dosing.

Manufacturers of supplements are not like drug companies who do studies and have extensive chemistry and toxicity data available on their products.

I don't think one can really put much trust in them therefore.
Here are some examples:

There are makers of B12 who put "take with food" on their directions. And this is absolutely wrong...as medical studies show poor or little absorption of microgram doses of drugs from the GI tract when food is present.

There are still timed release forms of B12 on the market and these don't work.

Cal/Mag/zinc supplements for the most part have magnesium oxide in them and do NOT provide absorption for that mineral. But they keep putting that form in their products, when it is now common knowledge that other forms of magnesium are better utilized.

Some makers still do not put elemental values of minerals on their product labels. (leading to confusing consumers about dosing).

In this case on this thread I see a clear intention of selling MORE enzyme to make more $$ for the maker, rather than
for the safety of the consumer.

Here is one opinion:
http://examine.com/supplements/serrapeptase/
Dr. Sahelian often has interesting comments about supplements. This link has consumer complaints about this supplement: Note he recommends much lower doses than discussed so far in this thread:
http://www.raysahelian.com/serrapeptase.html