Charlie...the more you speak of the "less more frequent" approach to Sinemet, the more I see the logic in it, and, as I already mentioned to you, we will present this to Doreen's "neuro" at her next visit.

ECD...thank you for your response about the medication and dosage that he takes. Doreen was initially taking Mirapex...same class of drugs as Requip...and it "worked" so well for her. If it had not been for the obsessive /compulsive side effect, I can readily say that this was a good medication for Doreen...she felt "all-round" very good and it all but eliminated the tremor. As with you and your husband, we, too, count our blessings that to date, she just has the tremor which, at times, is very annoying, but not debilitating...and for this we are grateful. Of course, it has recently increased to the point where it sometimes goes beyond "annoying" in that she works with an ENT cancer specialist as a medical assistant and shes finding that it's somewhat of a problem when she's handing the various instruments needed when working with the doctor...he doesn't see it as a problem, but Doreen does. Her "neuro" has always said..if the tremor ever DOES interfere with her work, then, it would be time to try to find something that will target it without the side effect of dyskinesia which she has experienced taking Sinemet. That is where we are right now...trying to find something that will at least alleviate the tremor without risking the side effect of dyskinesia...not an easy task. This is the reason that I think that Charlie's recommendation seems so logical, i.e., less more often...so, we'll see. I feel that, from what we know about the other symptoms of PD...if we were to have a choice of symptoms, we would opt for the tremor...seemingly a more difficult symptom to treat, but certainly a less debilitating symptom. As one of the doctors at"Ask the Doctor" has dubbed it...tremor is a very "moody" symptom.

Thanks again, ECS
Therese