Quote:
Originally Posted by rempatterson
Funny, an MDS told me that the problem with Sinemet losing its effect is due to the progression of the PD. Does anyone here have a research based fact on this subject?
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If this was true then “drug holiday” shouldn’t have worked in making Sinemet to be more effective again and yet it did for some PD patients as per this old study
http://www.ncbi.nlm.nih.gov/pubmed/7192805
Abruptly stopping or reducing the dose of Sinemet may cause a serious condition called neuroleptic malignant syndrome (NMS) so “drug holidays” are not recommended any more.