Hi John

My own experience leads me speculate whether the agonist associated daytime sleepiness is compounded by or caused by agonist induced insomnia. My regular 4 hours out, 2 hours awake has suddenly decreased to 2 hours out, 2 hours awake in line with increased requip dosage, I wonder if due to increased activity of the D3 receptor. If Iv remembered which one is linked to mood/serotonin ?
This perhaps links with point 3, our remaining ability to generate and store dopamine which is effectively done over night during sleep (I often feel good without meds between 2am - 5am) With insomnia,whatever the cause, we are probably not replenishing our natural supply efficiently and as the sleep deficit increases so the meds need to compensate. Small effect but part of the whole.

Nigel