I've discussed the pros and cons of Tysabri with my family (both boys and DIL) and they are concerned about the risk of PML.....especially since I am JCV positive.

I found an article that seemed pretty neutral but gave the hard facts about PML and the risk factors for JCV positive patients. It was a little scary to read I have to admit but I wanted them to know the facts.

They (well my boys at least) have already been through enough with the loss of family members and I don't feel I can risk putting them through another stressful situation for 2 years while I roll the dice with Ty. So it's a no-go for me.

While researching other MS drugs I found that many of the newer oral drugs also carry the PML risk. I was shocked! I remember specifically asking my Neuro if Tecfidera carried a PML risk and he said no. Well, I found a case of someone contracting a non-fatal case of PML after taking Tec! What the what???

http://www.medpagetoday.com/Neurolog...clerosis/52622.

Now not only do I have concerns about the safety of the MS meds but I question my Neuro's advice on everything now. He put me on Tec BEFORE testing me for the JC Virus!!! I think it's time to look for another Neuro. My confidence in him is gone now. His alternate drug to Ty was Gilenya. Well, looky what I found on it.....

http://www.fda.gov/Drugs/DrugSafety/ucm456919.htm.

I'm not sure where to turn or what to do.