For me, getting my thyroid supported after 10 long years of clinical depression from 1991 to 2002 and then getting Vit D3 tank filled up, got me out of a Long Depression.

A few years ago a friend visited a Psychiatrist who specializes in Depression naturally, gave out this printed sheet which the patient would take to the Pharmacy next door.

Vitamin B6 100 mg. one per day (in the form of P-5-P) (take now)

5-HTP 50 mg. one – twice per day. (have taken off and on)

Folapro 800 mcg. (5-methlytetrahydrofolate) one – twice per day. (take now)

Magnesium Glycinate one capsule twice daily. (take now, but more)

B12 Methylcobalamin 5000 mcg. sublingual per day (take 1-2Kmcg daily)

NutraSea Omega-3 Fish Oil. (take now, different brand)

NAC N-Acetyl-cysteine 500 mg. two capsules twice per day. (don't take)

I take all the above for different reasons, and for me SamE never worked, low dose and higher dosing. Adjust accordingly for one's needs.