I don't believe this is the stabilized form of R lipoic. That means you do need the high doses because it is not absorbed well.
300mg a day is an average dose of this, and should be on an empty stomach.
This is an example of the improved form, which has been modified to be more absorbable.
http://www.amazon.com/Doctors-Best-S.../dp/B000I4C19G
It is the one I use and some others here use also.
You only need one capsule a day of this.
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Weezie looking at petunias 8.25.2017
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