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Old 08-26-2015, 02:12 AM
johnt johnt is offline
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Join Date: Apr 2009
Location: Stafford, UK
Posts: 1,059
15 yr Member
johnt johnt is offline
Senior Member
 
Join Date: Apr 2009
Location: Stafford, UK
Posts: 1,059
15 yr Member
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Nigel,

You raise some interesting points.

I too seem to have reduced symptoms in the middle of the night, although I'm 12 hours or so from my last dose. I can put off my morning dose for hours and still perform pretty well, but once I take a pill I quickly deteriorate until its benefits kick in. Interestingly, when this wears off I'm much worse than I was during the night even though the last dose was much closer.

I think that your neurologist is right that it's to do with your remaining dopamine production. I think, however, that the real answer is more nuanced.

Based on a finger tapping argument I estimate that 60% of my dopamine is endogenous.

http://neurotalk.psychcentral.com/thread183360-2.html

See Post 17.

John
__________________
Born 1955. Diagnosed PD 2005.
Meds 2010-Nov 2016: Stalevo(75 mg) x 4, ropinirole xl 16 mg, rasagiline 1 mg
Current meds: Stalevo(75 mg) x 5, ropinirole xl 8 mg, rasagiline 1 mg
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