It can cause hot swollen welts in the skin that can be sore for a few days. Not every time, but sometimes. Yes, I have symptoms to a varying degree each week. I prefer Gamunex IV and am trying to go back to that since insurance denied my appeal for Hizentra. I have a port anyway, so so much less uncomfortable for me.

If I was going to an infusion center, which I've never done, I would probably find the Hizentra more appealing. Independence takes precedence for me.